Endocrine Abstracts

Introduction: There are not many studies specifying the role and contribution of adipocytokines in biology of adrenal gland cancer. Many research show correlation between increased level of serum visfatin and malignant potential, stage progression and prognosis. Visfatin/NAMPT overexpression has been found in a various type of malignances. So far, to the best of knowledge, this is the first research studying the role of visfatin in diagnosis of adrenal cortical carcin...

Introduction: Severe thyroid disorders are usually associated with myopathy. Muscle weakness may occur in both hypothyroidism and hyperthyroidism. However, only hypothyroid patients experience increase in creatine kinase levels, depicting destruction of muscle fibers. There were recently some reports showing the lowering in serum concentrations of large sarcomere proteins – titin (TTN) and dystrophin (DMD) in patients with hypo- and hyperthyroidism....

Introduction: Many original research studies describes significant impact of thyroid hormones on muscle tissue. Hypo- and hyperthyroidism cause both functional and structural damage of muscles presented by many signs and symptoms of thyroid myopathy. Thus, it is interesting to compare the impact of thyroid dysfunction on hormones secreted by muscles – myokines.Aim: The main goal of the project is to assess serum concentration of three myokines &#150...

Objective: The thyroid fine needle aspiration biopsy (FNAB) may bring inconclusive cytological results of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) or follicular neoplasm/suspicious for follicular neoplasm (FN/SFN). The objective of the study was to describe the genetic landscape of indeterminate thyroid nodules to better understand this phenomenon and identify genetic markers potentially differentiating benign and malignant ...

Introduction: Pre- and postsurgical differentiation between follicular thyroid adenoma (FTA) and follicular thyroid cancer (FTC) represents a significant diagnostic challenge. Typical markers of malignancy may appear as specific genetic alterations. Next-generation sequencing (NGS) studies bring information about single point mutations, however better insight into follicular thyroid lesions genetic landscape, encompassing bigger rearrangements, is needed.<p class="abstext"...